Endocrine Abstracts

The primary cilium of cells detects and transduces extracellular signals, in particular, amplifying the SHH pathway, a key pathway required for pituitary development. FUZ is a planar cell polarity (PCP) effector, which is essential for normal ciliogenesis, required for recruiting retrograde intraflagellar transport proteins to the base of the organelle. The primary cilia of Fuz-/- mutants are shorter or non-functional. Previous work has reported ciliopathy ...

Background: Impaired Insulin-like growth factor-1 (IGF-1) function is associated with obesity and hypertension, but the correlation of circulating IGF-1 with these conditions is weak. As a metabolite of IGF-1, the ratio of cGP/IGF-1 regulates IGF-1 bioavailability and may be a more accurate biomarker of IGF-1 function in obesity and hypertension.Methods: Using ELISA and HPLCms methodologies, we analysed plasma concentration of IGF-1, cGP and IGFBP-3 in 4...